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Clinical application of the multigene analysis test in discriminating between ulcerative colitis and Crohn's disease: a retrospective study
Sophiahemmet University College.
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2012 (English)In: Scandinavian journal of gastroenterology, ISSN 1502-7708, Vol. 47, no 2, 162-9 p.Article in journal (Refereed) Published
Abstract [en]

Abstract Methods. The newly described - multigene analysis test (DiBiCol) identifying 7 inflammatory bowel disease (IBD)-specific genes in colonic mucosal biopsy differentiating between ulcerative colitis (UC) and Crohn's disease (CD) with active inflammation - is a new addition to existing methods with a higher stated sensitivity and specificity. Method biopsy material from 78 patients with a complicated course diagnosed as most probably UC in 38, CD in 18 and inflammatory bowel disease unclassified (IBDU) in 22 were investigated by DiBiCol. Results. DiBiCol showed a pattern consistent with CD in 13 patients with UC and led to change of diagnosis in 3 patients and a strong suggestion of CD in 8 patients. A total of 2 patients remained as UC. DiBiCol showed a pattern of UC in 4 patients of 18 with CD leading to a changing of diagnosis to UC in 3 patients, but the fourth remained as CD. In 22 patients with IBDU DiBiCol showed a pattern consistent with UC in 7 cases and with CD in 13 cases. A new evaluation 1 year after the DiBiCol allowed the assessment of clinical diagnosis in 10 patients confirmed in 9 of 10 patients by DiBiCol. In patients with acute flare of colitis the clinical diagnosis corresponded in 10 of 12 UC and in 5 of 6 CD cases. Summary. Adopting the DiBiCol test led to a change of the primary diagnosis in a significant number of patients with the initial diagnosis of UC and CD and suggested a clinically probable diagnosis in most of the patients with IBDU and in those with an acute flare of colitis.

Place, publisher, year, edition, pages
2012. Vol. 47, no 2, 162-9 p.
Keyword [en]
DiBiCol, Inflammatory bowel diseases, Multigene analysis test
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:shh:diva-959DOI: 10.3109/00365521.2011.647065PubMedID: 22229803OAI: oai:DiVA.org:shh-959DiVA: diva2:501956
Available from: 2012-02-14 Created: 2012-02-14 Last updated: 2012-02-14Bibliographically approved

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