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Impaired absorption of insulin aspart from lipohypertrophic injection sites
Sophiahemmet University.ORCID iD: 0000-0003-3309-136X
Sophiahemmet University.
Sophiahemmet University.
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2005 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 28, no 8, 2025-7 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2005. Vol. 28, no 8, 2025-7 p.
National Category
Nursing
Identifiers
URN: urn:nbn:se:shh:diva-9PubMedID: 16043749OAI: oai:DiVA.org:shh-9DiVA: diva2:302145
Available from: 2010-03-04 Created: 2010-02-17 Last updated: 2014-09-29Bibliographically approved
In thesis
1. Health Promotion in Diabetes Care: Studies on Adult Type 1 Diabetes Patients
Open this publication in new window or tab >>Health Promotion in Diabetes Care: Studies on Adult Type 1 Diabetes Patients
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Introduction: A landmark report has shown that improving glycaemic control among type 1 diabetes patients markedly reduces diabetes-related complications. In clinical practice, however, many patients have problems in adhering to the treatment, and thus remain in poor glycaemic control. Research suggests a more behaviour-oriented approach to diabetes, but there is a lack of evidence on the efficacy of interventions, especially for those adult type 1 diabetes patients who are in poor glycaemic control. Diabetes-related distress has been associated with poor adherence to treatment and poor glycaemic control. There is a need for validated measures in this area, to identify patients who experience diabetes-related distress. Additionally, injection technique is crucial for the management of diabetes, and lipohypertrophy is a common side effect which deserves further attention.

Objectives: The overall aim of this thesis was to evaluate a behavioural medicine intervention among poorly controlled adult type 1 diabetes patients, and to gain a deeper knowledge in an area of diabetes self-management.

Methods: Quantitative design was used for the studies, and the clinical settings comprised two diabetes care units in Stockholm, Sweden. Study I: The Swedish version of the Problem Areas in Diabetes (Swe-PAID-20) scale was evaluated regarding its psychometric properties by type 1 diabetes patients, as well as by an expert panel of diabetes specialist nurses. Study II: A behavioural medicine intervention based on Cognitive Behaviour Therapy (CBT) was evaluated in a randomised controlled trial among poorly controlled adult type 1 diabetes patients. Study III: Using the same sample as in study II, descriptive statistics were produced, and predictive and comparative analyses performed, in order to find predictors of or associations with improvements in glycaemic control as a response to the intervention. Study IV: In a randomised crossover trial insulin absorption in lipohypertrophic injection sites was investigated in type 1 diabetes patients.

Results and conclusions: Study I: A three-factor solution of the scale was found, comprising sub-dimensions of diabetes-related emotional problems, treatment-related problems and support-related problems. Cronbach’s alpha for the total score was 0.94 and varied between 0.61 and 0.94 in the three subscales. The findings also supported the convergent and content validity. The Swe-PAID-20 seems to be a reliable and valid outcome for measuring diabetes-related distress in type 1 diabetes patients. Study II: Significant differences were observed with respect to HbA1c, well-being, diabetes-related distress, frequency of blood glucose testing, fear of hypoglycaemia, perceived stress, and depression, all of which improved more in the intervention group compared with the control group. The CBT based behavioural medicine intervention appears to be a promising approach to diabetes self-management. Study III: The participation rate in the study was 41% and attrition was 24%. Of those patients who actually participated in the intervention, 13% withdrew. From the regression models no predictors or associations were found with regard to improvement in HbA1c. The programme proved to be feasible in terms of design and methods. However, no clear pattern was found regarding predictors of or associations with improved metabolic control. Study IV: Impairment of insulin absorption from lipohypertrophic injection sites was also found with analogue insulins. It is suggested that patients should be advised to refrain from injecting insulin aspart into lipohypertrophic subcutaneous tissue.

Place, publisher, year, edition, pages
Stockholm: Karolinska Institutet, 2008. 58 p.
Keyword
Type 1 diabetes, Diabetes-related distress, Psychometrics, Behaviour modification, Cognitive behaviour therapy, Behavioural medicine, Glycaemic control, Predictor, Lipohypertrophy, Insulin absorption, Injection technique
National Category
Nursing
Identifiers
urn:nbn:se:shh:diva-128 (URN)978-91-7357-566-9 (ISBN)
Public defence
2008-05-23, 09:00 (English)
Opponent
Supervisors
Available from: 2010-04-27 Created: 2010-03-05 Last updated: 2016-06-09Bibliographically approved

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