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The EXPANd trial: effects of exercise and exploring neuroplastic changes in people with Parkinson's disease
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2019 (English)In: BMC Neurology, ISSN 1471-2377, E-ISSN 1471-2377, Vol. 19, no 1, article id 280Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Parkinson's disease (PD) affects many physiological systems essential for balance control. Recent studies suggest that intensive and cognitively demanding physical exercise programs are capable of inducing plastic brain changes in PD. We have developed a highly challenging balance training (the HiBalance) program that emphasizes critical aspects of balance control through progressively introducing more challenging exercises which incorporates dual-tasking. Earlier studies have shown it to be effective in improving balance, gait and dual-tasking. The study design has thereafter been adjusted to link intervention-induced behavioral changes to brain morphology and function. Specifically, in this randomized controlled trial, we will determine the effects of the HiBalance program on balance, gait and cognition and relate this to task-evoked functional MRI (fMRI), as well as brain-derived neurotrophic factor (BDNF) in participants with mild-moderate PD.

METHODS: One hundred participants with idiopathic PD, Hoehn & Yahr stage 2 or 3, ≥ 60 years of age, ≥ 21 on Montreal Cognitive Assessment will be recruited in successive waves and randomized into either the HiBalance program or to an active control group (the HiCommunication program, targeting speech and communication). Both interventions will be performed in small groups, twice a week with 1 h sessions for 10 weeks. In addition, a 1 h, once a week, home exercise program will also be performed. A double-blinded design will be used. At the pre- and post-assessments, participants will be assessed on balance (main outcome), gait, cognitive functions, physical activity, voice/speech function, BDNF in serum and fMRI (3 T Philips) during performance of motor-cognitive tasks.

DISCUSSION: Since there is currently no cure for PD, findings of neuroplastic brain changes in response to exercise would revolutionize the way we treat PD, and, in turn, provide new hope to patients for a life with better health, greater independence and improved quality of life.

TRIAL REGISTRATION: ClincalTrials.gov: NCT03213873, first posted July 11, 2017.

Place, publisher, year, edition, pages
2019. Vol. 19, no 1, article id 280
Keywords [en]
Balance, Cognition, Dual-task, Exercise, Gait, Imaging, Magnetic resonance neural growth factor, Neuroplasticity, Parkinson’s disease
National Category
Physiotherapy
Identifiers
URN: urn:nbn:se:shh:diva-3509DOI: 10.1186/s12883-019-1520-2PubMedID: 31718583OAI: oai:DiVA.org:shh-3509DiVA, id: diva2:1373124
Available from: 2019-11-26 Created: 2019-11-26 Last updated: 2019-11-26Bibliographically approved

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