shh.sePublications
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Correlations between insulin-degrading enzyme and metabolic markers in patients diagnosed with type 2 diabetes, Alzheimer's disease, and healthy controls: A comparative study
Sophiahemmet University.ORCID iD: 0000-0002-0785-7029
Sophiahemmet University.ORCID iD: 0000-0003-4920-252x
Sophiahemmet University.ORCID iD: 0000-0003-3309-136x
Sophiahemmet University.ORCID iD: 0000-0002-4607-8677
Show others and affiliations
2023 (English)In: Endocrine, ISSN 1355-008X, E-ISSN 1559-0100Article in journal (Refereed) Epub ahead of print
Abstract [en]

PURPOSE: This study aimed to explore correlations between insulin-degrading enzyme (IDE) and markers of metabolic function in a group of patients diagnosed with type 2 diabetes mellitus (T2DM) or Alzheimer's disease (AD) and metabolically healthy volunteers.

METHOD: We included 120 individuals (47 with T2DM, 9 with AD, and 64 healthy controls). Serum levels of IDE were measured with commercial kits for ELISA. Differences in IDE levels between groups were analyzed with non-parametric ANCOVA, and correlations were analyzed with Spearman's rank correlations. We also investigated the influence of age, sex, and the use of insulin on the correlation using a non-parametric version of partial correlation.

RESULTS: Patients diagnosed with T2DM had higher IDE levels than patients diagnosed with AD and healthy controls after adjustment for age and sex. IDE was increasingly associated with body mass index (BMI), fasting blood glucose, C-peptide, hemoglobin A1c (HbA1c), insulin resistance, and triglycerides. In stratified analyses, we found a decreasing partial correlation between IDE and HbA1c in patients diagnosed with AD and a decreasing partial correlation between IDE and C-peptide in healthy controls. In patients diagnosed with T2DM, we found no partial correlations.

CONCLUSION: These results indicate that IDE is essential in metabolic function and might reflect metabolic status, although it is not yet a biomarker that can be utilized in clinical practice. Further research on IDE in human blood may provide crucial insights into the full function of the enzyme.

Place, publisher, year, edition, pages
2023.
Keywords [en]
Alzheimer’s disease, Insulin resistance, Insulin-degrading enzyme, Metabolic disorder, Serum, Type 2 diabetes mellitus
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:shh:diva-5079DOI: 10.1007/s12020-023-03603-4PubMedID: 37980298OAI: oai:DiVA.org:shh-5079DiVA, id: diva2:1814194
Available from: 2023-11-23 Created: 2023-11-23 Last updated: 2023-11-23Bibliographically approved

Open Access in DiVA

fulltext(671 kB)15 downloads
File information
File name FULLTEXT01.pdfFile size 671 kBChecksum SHA-512
6eea7dcf63fc607e6c8744ede357a69a0fc2b76635d56fe3c8d2f17d0cd8c3b5eddb59505b1246a12b4d2893da3e6f5ac85e521c9bfecf239dd3ca7ee57aa715
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records

Kullenberg, HelenaRossen, JennyJohansson, Unn-BrittHagströmer, MariaKumlin, MariaSvedberg, Marie

Search in DiVA

By author/editor
Kullenberg, HelenaRossen, JennyJohansson, Unn-BrittHagströmer, MariaKumlin, MariaSvedberg, Marie
By organisation
Sophiahemmet University
In the same journal
Endocrine
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 15 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 103 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf